{
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  "status": "documented_historical_discovery_and_reconciliation",
  "provider": "Consensus",
  "provider_mode": "Historical browser/connector use as recorded in the source artifacts",
  "local_audit_date": "2026-10-09",
  "primary_comparison_count": null,
  "reported_usage": [],
  "grade_changed": false,
  "score_before": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "Moderate",
    "confidence_rationale": "Evidence density is high for the efficacy clause and moderate for the serotonin clause, but reproducibility in the serotonin literature is demonstrably poor: the candidate-gene and gene-by-stress programme collapsed in the largest samples (C7, C8), the imaging findings are inconsistent across reviews and confounded by medication history (C1), the depletion literature is heterogeneous in protocol and partly concentrated in overlapping groups (C3, C4), and the single direct measure of release capacity is unreplicated with 17 patients (C6). That is the framework's description of Moderate, not High. The input grading's High rested on a base of eight abstract-only sources of which four carried identifiers pointing at unrelated papers.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "Weakest-link over SC1=Γ, SC2=Γ, SC3=Γ, SC4=Δ gives Γ. The mechanism is plausible and has partial human support - an unblinded challenge study, the pharmacology of the drugs themselves, and one positive human mediator manipulation; what has not been shown is the endogenous, disease-relevant causal dependency the claim asserts - that a serotonin deficiency exists in depression and that correcting it is how treatment works."
  },
  "score_after": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "Moderate",
    "confidence_rationale": "Evidence density is high for the efficacy clause and moderate for the serotonin clause, but reproducibility in the serotonin literature is demonstrably poor: the candidate-gene and gene-by-stress programme collapsed in the largest samples (C7, C8), the imaging findings are inconsistent across reviews and confounded by medication history (C1), the depletion literature is heterogeneous in protocol and partly concentrated in overlapping groups (C3, C4), and the single direct measure of release capacity is unreplicated with 17 patients (C6). That is the framework's description of Moderate, not High. The input grading's High rested on a base of eight abstract-only sources of which four carried identifiers pointing at unrelated papers.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "Weakest-link over SC1=Γ, SC2=Γ, SC3=Γ, SC4=Δ gives Γ. The mechanism is plausible and has partial human support - an unblinded challenge study, the pharmacology of the drugs themselves, and one positive human mediator manipulation; what has not been shown is the endogenous, disease-relevant causal dependency the claim asserts - that a serotonin deficiency exists in depression and that correcting it is how treatment works."
  },
  "independent_blinded_audit": false,
  "raw_receipts": [
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      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\mdd-serotonin\\consensus-browser.txt",
      "sha256": "ccc4d01cd433871b4d98c4a20673ff21ead4c7fe288daef50d9afc35b50a894b"
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    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\mdd-serotonin\\consensus-targeted-check.txt",
      "sha256": "d630080a417e70beeeeb605c4a5b6ad8df92321db85f5905fe88cd2854eefd6f"
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  "limitations": "This verifies documented historical use and links the record to the final edition. It adds no primary-source, full-text, independence or verification credit. Original access remains limited to the source-specific record.",
  "existing_primary_reconciliation": {
    "slug": "mdd-serotonin",
    "consensus_used": true,
    "rawproof": [
      "deliverables/prepublication-enrichment-2026-10-05/website-series/mdd-serotonin/consensus-browser.txt",
      "deliverables/prepublication-enrichment-2026-10-05/website-series/mdd-serotonin/consensus-targeted-check.txt",
      "deliverables/prepublication-enrichment-2026-10-05/website-series/mdd-serotonin/consensus-browser-links.json"
    ],
    "reconciliation_existing": "Yes; 7 distinct primary identifiers, abstract/metadata checks documented; excludes unrelated PMID from verification.",
    "primary_sources_matched": [
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    "limitations": "No independently readable body verified; update explicitly avoids padding with meta-analyses."
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}