{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Gut microbes differ between people and can affect metabolism or behavior in experiments. This review asks when those effects contribute to human disease and whether microbiome composition is a primary cause across diseases.",
  "implications": "SC4 is the preregistered human-primacy gate. Transfers, defined strains and microbial products show real bounded contributions, and HE intervention crosses human contribution thresholds, but none establishes composition as the primary upstream target across systemic and neurobehavioural disease. SC1 association is Β, bounded rodent causality SC2 Ζ, human contribution SC3 Ε, broad primacy SC4 Γ. These are different scopes, not a refutation of the microbiome.",
  "limitations": "67 primary reports with 8 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}