{
  "slug": "mitochondrial-cascade",
  "round": 2,
  "date": "2026-10-14",
  "authoring_model": "Sol 6.1",
  "reviewer": "Claude Opus 5.5 (Anthropic)",
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "pmids_checked": 70,
  "pmids_failed": 0,
  "claims_spot_checked": 10,
  "validator": "FAIL (v5.lay_summary only, pre-existing); 31 PASS, 2 WARN",
  "findings": [
    {
      "id": "M-1",
      "severity": "Major",
      "location": "Consensus provenance reconciliation — 9 October 2026",
      "original": "The earlier adversarial approval refers to its original edition",
      "corrected": "No earlier adversarial approval exists for this case",
      "evidence": "No approval section/banner/line in any edition incl. hsef_v53_popularity_ranks_26_30_2026-10-07 copy; regression introduced by the Oct 9 revision",
      "type": "false_approval_reference"
    },
    {
      "id": "M-2",
      "severity": "Minor",
      "location": "REFERENCES [31]",
      "original": "31.   et al.",
      "corrected": "31. HD iPSC Consortium.",
      "evidence": "PubMed CollectiveName, PMID 30768179",
      "type": "collective_author_dropped"
    },
    {
      "id": "M-3",
      "severity": "Minor",
      "location": "REFERENCES [58]",
      "original": "58.  ,   et al.",
      "corrected": "58. Writing Group, Edaravone (MCI-186) ALS 19 Study Group.",
      "evidence": "PubMed CollectiveName x2, PMID 28522181",
      "type": "collective_author_dropped"
    },
    {
      "id": "M-4",
      "severity": "Minor",
      "location": "REFERENCES [64]",
      "original": "64.  , Beal MF, Oakes D et al.",
      "corrected": "64. Parkinson Study Group QE3 Investigators, Beal MF, Oakes D et al.",
      "evidence": "PubMed CollectiveName, PMID 24664227",
      "type": "collective_author_dropped"
    },
    {
      "id": "M-5",
      "severity": "Minor",
      "location": "REFERENCES [65]",
      "original": "65.  , Kieburtz K, Tilley BC et al.",
      "corrected": "65. Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC et al.",
      "evidence": "PubMed CollectiveName, PMID 25668262",
      "type": "collective_author_dropped"
    },
    {
      "id": "M-6",
      "severity": "Minor",
      "location": "REFERENCES [66]",
      "original": "66.   et al.",
      "corrected": "66. Parkinson Study Group STEADY-PD III Investigators.",
      "evidence": "PubMed CollectiveName, PMID 32227247",
      "type": "collective_author_dropped"
    },
    {
      "id": "M-7",
      "severity": "Minor",
      "location": "scorecard final_score.confidence_rationale (x3)",
      "original": "density, heterogeneous controls and incomplete access set the confidence",
      "corrected": "restated as evidence density and reproducibility; access depth explicitly excluded",
      "evidence": "hsef-framework.md confidence band section; lead confidence-band policy 2026-10-14. Band re-derived: Moderate stands on documented reproducibility concerns",
      "type": "confidence_band_rationale"
    },
    {
      "id": "M-8",
      "severity": "Editorial",
      "location": "REFERENCES [44]; evidence card [60]",
      "original": "DOI: . / ErratumIn: PMIDnot supplied.",
      "corrected": "DOI field dropped / ErratumIn: PMID not supplied.",
      "evidence": "PubMed holds no DOI for PMID 10939564; ErratumIn for PMID 24067398 has RefSource without PMID",
      "type": "rendering_defect"
    }
  ],
  "rejected_findings": [
    {
      "item": "headline Γ and scope-matched derivation",
      "reason": "SC5 is the only scope-matched subclaim; SC2 ζ is scope-restricted; alternatives reported as required"
    },
    {
      "item": "Best-supported rival renderer artifact",
      "reason": "rank 1 Multi-hit convergent loop is not the nominal model (nominal ranks 4)"
    },
    {
      "item": "Momentum value",
      "reason": "'Mechanistic only' with naming artifact present; no 'Decisive work underway' claim"
    },
    {
      "item": "REVIEWER NOTES vs spliced Consensus section",
      "reason": "notes record two Consensus Pro queries; no 'no Consensus work' claim to reconcile"
    },
    {
      "item": "reference [16] year 2023 vs e-pub 2022",
      "reason": "±1 print/e-pub convention"
    },
    {
      "item": "PubMed title 'Pink1mice' (PMID 31316206)",
      "reason": "PubMed drops superscripts; review form is correct"
    },
    {
      "item": "UDCA n=31 vs abstract n=30",
      "reason": "verified against original Results PMC10527073: 31 randomised, 25 MRS, 18 gait — review correct"
    },
    {
      "item": "v5.claim_form 'phenomenon' warning",
      "reason": "registered claim states causal primacy plus consequence"
    }
  ],
  "propagate_to": [],
  "divergent_copies": [
    "hsef_v53_popularity_ranks_26_30_2026-10-07/mitochondrial-cascade/mitochondrial-cascade.review.md"
  ],
  "approval": "Approved as revised"
}