{
  "completed": true,
  "status": "completed_original_source_reconciliation",
  "provider_mode": "Consensus Pro signed-in browser; observed output and citation link mappings",
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    "https://consensus.app/search/mots-c-mitochondrial-peptide-metabolism/8p8nFrY3Q5qnDyJaFh4rKA/"
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  "query_record_note": "Exact visible question/response retained privately in raw browser receipt.",
  "primary_comparison_count": 8,
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    {
      "pmid": "25738459",
      "doi": "10.1016/j.cmet.2015.02.009",
      "source_type": "primary study report",
      "study_group": "PMID25738459",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Mitochondrial genomic origin and translation compartment",
      "result_comparison": "Original Results0–1 report12S-region coding potential, NUMT searches and loss of immunodetected peptide/transcripts after rho0oractinonin depletion. Cytoplasmic translation is an inference from the standard versus mitochondrial genetic code; native export/translation was not directly tracked. Provider genome-origin wording should not become proof of mitoribosomal production or complete native assay validation.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/25738459/",
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    },
    {
      "pmid": "33473109",
      "doi": "10.1038/s41467-020-20790-0",
      "source_type": "primary study report",
      "study_group": "PMID33473109",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Late-life dosing, functional healthspan and survival",
      "result_comparison": "Original Results6/8 verify male C57BL6/N functional gains and intermittent15mg/kg3times/week dosing beginning around23.5months. Overall survival is nonsignificant P=0.23. Food intake differs during late-life treatment, so the provider's no-hyperphagia description is not retained; a restricted early survival comparison is not whole-curve lifespan extension.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/33473109/",
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    {
      "pmid": "33468709",
      "doi": "10.18632/aging.202529",
      "source_type": "primary study report",
      "study_group": "MOTS_K14Q_JMICC_MEC_TMM",
      "access_depth": "full_text_partial",
      "consensus_aspect": "K14Q genotype and12S-rRNA structural alternative",
      "result_comparison": "Original Results0 predicts little12S-rRNA secondary-structure difference, not direct demonstrated structural perturbation as the provider states. Results6 shows female mouse WT/K14Q nulls, and cohort effects are sex/activity dependent. rRNA/linkedmtDNA effects remain possible rather than proven.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/33468709/",
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    {
      "pmid": "39559755",
      "doi": "10.1016/j.isci.2024.111212",
      "source_type": "primary study report",
      "study_group": "MOTS_K14Q_CK2_WITH_JMICC_COMPONENT",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Direct target and native assay specificity",
      "result_comparison": "Original Results7/15/42 verify supplied-peptide SPR binding and CK2-dependent uptake through inhibitor/cellularASO controls. Muscle/adipose kinase effects differ and an input immunoblot has an acknowledged nonspecific band. Synthetic target binding supports pharmacology but does not validate every native ELISA signal.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/39559755/",
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    {
      "pmid": "41520850",
      "doi": "10.1016/j.freeradbiomed.2026.01.002",
      "source_type": "primary study report",
      "study_group": "PMID41520850",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Human exercise trans-organ flux",
      "result_comparison": "Complete original PubMed abstract verifies increased human interstitial peptide with no changed arterio-venous difference, plus mouse PGC1alpha/AMPK dependence of mitochondrial metrics. Provider muscle-source caution is supported, but absence of a gradient is not proof of zero muscle secretion. This source was examined at abstract depth, not full-text depth.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/41520850/",
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    {
      "pmid": "42324588",
      "doi": "10.1186/s41232-026-00431-7",
      "source_type": "primary study report",
      "study_group": "PMID42324588",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Positive AMPK signal versus functional repair",
      "result_comparison": "Original Results3/5/7/11 show AMPK activation with adverse senescence/inflammatory changes and impaired repair after humanMSCpretreatment/transplantation in mice. This original negative-context test is missing from the provider synthesis and prevents signaling activation from being promoted to general regenerative benefit.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/42324588/",
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      ]
    },
    {
      "pmid": "41551324",
      "doi": "10.1016/j.jcte.2025.100429",
      "source_type": "primary study report",
      "study_group": "OBESITY_BARIATRIC_MOTS_PARENT",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Human systemic-marker direction and mediation",
      "result_comparison": "Original Results5/19/22 show higher adult-obesity peptide measurements and no significant peptide change despite postsurgery metabolic/weight improvement. Abstract, body and table numeric summaries disagree, so the review retains direction/null status without an invented corrected value. Provider generalized deficiency framing is incomplete.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/41551324/",
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    },
    {
      "pmid": "39457696",
      "doi": "10.3390/biomedicines12102384",
      "source_type": "primary study report",
      "study_group": "PMID39457696",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Opposite genotype-performance context",
      "result_comparison": "Complete original abstract reports higher muscle mass/grip among older Korean male C-allele carriers, with female nulls. This qualifies the provider's adverse-K14Q framing; observational population results are not proof of peptide dosing benefit or harm.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/39457696/",
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      "body_receipts": []
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  "grade_changed": false,
  "grade_change_note": "Source-based adjudication; no independent blinded regrade claimed.",
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  "independent_blinded_audit": false,
  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T19:55:27.108848+00:00",
  "conclusion": "Endpoint hierarchy, experimental scope and original-source limits determine the evidence cards; provider wording does not override them."
}