Selected publication milestones, not an exhaustive history or discovery priority claim.
1986 — Experimental upper-airway mechanics precede modern taping claims. Original PMID3093456.
1993 — Waking CT reveals different regional responses to oral versus nasal breathing. Original PMID8131434.
1999 — Random-order ventilation nights identify leak and assisted-support effects. Original PMID10624751.
2004 — Chinstrap reduces assisted leak while increasing snoring in some users. Original PMID15165532.
2005 — Controlled nasal treatment shows a separate upstream contribution to mouth breathing and OSA. Original PMID15738298.
2015 — Thirty-person porous-patch pilot reports a positive uncontrolled mild-OSA signal. Original PMID25450408.
2018 — Natural-sleep palatal prolapse provides a compensatory-route explanation. Original PMID29444914.
2020 — Sedated closure anatomy is studied but does not isolate natural-sleep tape efficacy. Original PMID32162059.
2022 — Large multinight dataset documents single-night diagnostic variability. Original PMID34904935.
2022 — Retrospective mild-OSA tape pilot reports objective improvement with selection and co-treatment limits. Original PMID36141367.
2023 — Fixed-order puffing study identifies many nonimproved outcomes. Original PMID37032816.
2024 — Alternating-breath endoscopy finds bidirectional flow changes by baseline oral breathing. Original PMID39361293.
2025 — Randomized CPAP-adjunct trial demonstrates a distinct adherence benefit. Original PMID40963295.
2025 — Clinical ring validation exposes substantial individual errors despite acceptable group averages. Original PMID40108409.
A controlled tape-alone natural-sleep trial with adequate multi-night precision.
A prospective baseline classifier that distinguishes compensatory oral breathing from modifiable mouth opening.
Durable functional benefit beyond snoring or a single apnea index.
Patient-level safety and intolerance rather than only tolerated-user efficacy.
Endpoint- and device-specific validation of consumer tracking, independent of treatment efficacy.
A preregistered randomized crossover of the exact tape product versus credible sham/usual breathing in adults with baseline mouth-breathing OSA, with multiple nights per phase, blinded PSG scoring, washout/order balance, predefined nasal and velopharyngeal strata, and complete intolerance/adverse-event capture.