Cutoff: 9 October 2026. Consensus supports discovery and checks of specific source aspects; it is not a primary study, a full-paper audit or a causal probability meter.
Original2018publication Results confirms matched cell-cycle profiles, topology changes and partial laminB1add-back rescue, but no enrichment for expression changes among NL-associated genes. Detached LAD genes are not preferentially upregulated. Its publication-year2018is preserved separately from the provider's2017label; the source is not simply a transcriptional null. Original PMID30201095. Access: full_text_partial.
Original body verifies ESC growth/pluripotency and induced TE differentiation without detectable laminA/C orB, with no relationship between bound promoters and RNA changes. This is a defined native context and does not imply every tissue is lamin-independent. Original PMID22116031. Access: full_text_partial.
Original body agrees and identifies membrane-tether redundancy. Additional B-lamin depletion does not enhance the defined LBR/LAP2 loss phenotype. Long-term transcriptome changes include stress/TF amplification and mixed directions; weak H3K27me3-expression correlation does not establish a recruited-enzyme mechanism. Original PMID41735607. Access: full_text_partial.
Original Results retains a modest LMNB1hit inLAD5and null inLAD6, inability to exclude essential/redundant factors, and NELF native-RNAeffects whose apparent LAD preference reduces after expression matching. The screen cannot be declared a universal proof of no lamin contribution. Original PMID39322756. Access: full_text_partial.
Original Results showsHDAC1silencing with no significant contact loss,HDAC3contact loss without comparable repression, and redundant LEM effects. It supports local causality while separating enzyme necessity from lamina-specific recruitment necessity. Original PMID23226217. Access: full_text_partial.
Original Results showsGata4reduction/allele rescue and opposite effects whenA-type lamins are depleted in naive stem versus progenitor/cardiomyocyte stages. B1lossdoes not largely mimic cardiac differentiation. Contextual lamina regulation survives the global-repression challenge. Original PMID36333314. Access: full_text_partial.
Original body defines a4Mbmulticopytransgene array whose peripheral transcription can be induced with similar kinetics. This is a meaningful synthetic countertest to universal position-silencing, but it is not every native gene and must remain labeled artificial. Original PMID18195101. Access: full_text_partial.
Original primary record and selectedMethods/Results verify the2026peer-reviewed paper: H1299CRISPR clones, lower nascentRNA, correlated speckle-distance/RNAchanges and increased death/apoptosis with reduced proliferation. Selectedbodyalso notes shRNA apoptosis replication. The source was added to the corpus as an actual examined lead; a selective speckle-distance mediator is not independently isolated. Original PMID41909953. Access: full_text_partial.
Original updated2025abstract showsCEC4lossaffects constrained nuclear migration in aLINC-defectivecontext and a lamin-stabilizing mutation rescues. Anchoring has a mechanical role; this cannot be converted to global transcriptional repression. Its earlier2024preprint is excluded from separate primary credit. Original PMID40335054. Access: abstract_metadata.
Consensus was used to identify literature and cross-check specific claims about design, endpoints, scope and research gaps. Those aspects were checked against original primary abstracts/status records and selected original Methods/Results passages. Consensus output was not treated as original full text. Provider search omissions are not evidence that a study does not exist. Source access and examination receipts are retained. Scite use or monthly unavailability is recorded per case; provider citation counts do not change causal grades.