{
  "completed": true,
  "status": "completed_original_source_reconciliation",
  "provider_mode": "Consensus Pro signed-in browser; observed output and citation link mappings",
  "queries": [
    "https://consensus.app/search/lamins-transcriptional-repression-mechanisms/QKKFuu3RReuV471jflJXMw/"
  ],
  "query_record_note": "Exact visible question/response retained privately in raw browser receipt.",
  "primary_comparison_count": 9,
  "primary_comparisons": [
    {
      "pmid": "30201095",
      "doi": "10.1016/j.molcel.2018.05.017",
      "source_type": "primary study report",
      "study_group": "MOUSE_LAMIN_NULL_ESC_SERIES",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus says major lamin loss does not cause global LAD derepression and links Zheng as2017.",
      "result_comparison": "Original2018publication Results confirms matched cell-cycle profiles, topology changes and partial laminB1add-back rescue, but no enrichment for expression changes among NL-associated genes. Detached LAD genes are not preferentially upregulated. Its publication-year2018is preserved separately from the provider's2017label; the source is not simply a transcriptional null.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/30201095/",
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      ]
    },
    {
      "pmid": "22116031",
      "doi": "10.1126/science.1211222",
      "source_type": "primary study report",
      "study_group": "MOUSE_LAMIN_NULL_ESC_SERIES",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Provider emphasizes lamin-null stem-cell exceptions.",
      "result_comparison": "Original body verifies ESC growth/pluripotency and induced TE differentiation without detectable laminA/C orB, with no relationship between bound promoters and RNA changes. This is a defined native context and does not imply every tissue is lamin-independent.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/22116031/",
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      ]
    },
    {
      "pmid": "41735607",
      "doi": "10.1038/s41556-025-01822-7",
      "source_type": "primary study report",
      "study_group": "PMID41735607",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus contrasts mild72hourRNAchange with major chronic LBR/LAP2KOeffects.",
      "result_comparison": "Original body agrees and identifies membrane-tether redundancy. Additional B-lamin depletion does not enhance the defined LBR/LAP2 loss phenotype. Long-term transcriptome changes include stress/TF amplification and mixed directions; weak H3K27me3-expression correlation does not establish a recruited-enzyme mechanism.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/41735607/",
      "source_examination_receipts": [
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      ]
    },
    {
      "pmid": "39322756",
      "doi": "10.1038/s44318-024-00214-1",
      "source_type": "primary study report",
      "study_group": "PMID39322756",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Provider uses the2024LADscreen as evidence for chromatin regulators rather than lamin-only repression.",
      "result_comparison": "Original Results retains a modest LMNB1hit inLAD5and null inLAD6, inability to exclude essential/redundant factors, and NELF native-RNAeffects whose apparent LAD preference reduces after expression matching. The screen cannot be declared a universal proof of no lamin contribution.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/39322756/",
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      ]
    },
    {
      "pmid": "23226217",
      "doi": "10.1371/journal.pone.0049692",
      "source_type": "primary study report",
      "study_group": "PMID23226217",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Provider discusses local enzymatic repressors but does not detail the named flyHDACmechanistic split.",
      "result_comparison": "Original Results showsHDAC1silencing with no significant contact loss,HDAC3contact loss without comparable repression, and redundant LEM effects. It supports local causality while separating enzyme necessity from lamina-specific recruitment necessity.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/23226217/",
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      ]
    },
    {
      "pmid": "36333314",
      "doi": "10.1038/s41467-022-34366-7",
      "source_type": "primary study report",
      "study_group": "PMID36333314",
      "access_depth": "full_text_partial",
      "consensus_aspect": "The requested Gata4-rescue/stem-state primary is not materially discussed in the observed synthesis.",
      "result_comparison": "Original Results showsGata4reduction/allele rescue and opposite effects whenA-type lamins are depleted in naive stem versus progenitor/cardiomyocyte stages. B1lossdoes not largely mimic cardiac differentiation. Contextual lamina regulation survives the global-repression challenge.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/36333314/",
      "source_examination_receipts": [
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    },
    {
      "pmid": "18195101",
      "doi": "10.1083/jcb.200706060",
      "source_type": "primary study report",
      "study_group": "PMID18195101",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus says synthetic peripheral tethering is sometimes sufficient and not decisive.",
      "result_comparison": "Original body defines a4Mbmulticopytransgene array whose peripheral transcription can be induced with similar kinetics. This is a meaningful synthetic countertest to universal position-silencing, but it is not every native gene and must remain labeled artificial.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/18195101/",
      "source_examination_receipts": [
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      ]
    },
    {
      "pmid": "41909953",
      "doi": "10.1093/nar/gkag283",
      "source_type": "primary study report",
      "study_group": "PMID41909953",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus supplies a new2026B-lamin/speckle primary and reports more-than-half lower nascentRNA.",
      "result_comparison": "Original primary record and selectedMethods/Results verify the2026peer-reviewed paper: H1299CRISPR clones, lower nascentRNA, correlated speckle-distance/RNAchanges and increased death/apoptosis with reduced proliferation. Selectedbodyalso notes shRNA apoptosis replication. The source was added to the corpus as an actual examined lead; a selective speckle-distance mediator is not independently isolated.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/41909953/",
      "source_examination_receipts": [
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      ]
    },
    {
      "pmid": "40335054",
      "doi": "10.1093/genetics/iyaf086",
      "source_type": "primary study report",
      "study_group": "PMID40335054",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "The requested worm anchoring/mechanics primary is not detailed by the provider.",
      "result_comparison": "Original updated2025abstract showsCEC4lossaffects constrained nuclear migration in aLINC-defectivecontext and a lamin-stabilizing mutation rescues. Anchoring has a mechanical role; this cannot be converted to global transcriptional repression. Its earlier2024preprint is excluded from separate primary credit.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/40335054/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_16_19_2026-10-12\\nuclear-lamina\\examinations\\original-30-45-2800.json"
      ],
      "body_receipts": []
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  ],
  "grade_changed": false,
  "grade_change_note": "Source-based adjudication; no independent blinded regrade claimed.",
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  "independent_blinded_audit": false,
  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T20:10:07.590764+00:00",
  "conclusion": "Endpoint hierarchy, experimental scope and original-source limits determine the evidence cards; provider wording does not override them."
}