{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used bounded original primary abstract passages/status records and selected original partial-body passages. No complete-abstract or complete-paper audit, or independent scientific peer review, is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Lamins help organize genomes and regulate genes in defined settings; peripheral contact is not a universal gene-off switch, and global lamina-driven enzymatic silencing remains unestablished.",
  "implications": "Scope-matched aggregation is fixed to global SC4 and yields Γ. SC2 has mapped context-specific Ε support, while SC1 remains Β and direct enzyme-recruitment necessity SC3 remains Γ. Whole-lamin deletion can change thousands of genes yet still fail to establish direct global repression: changes can be bidirectional, follow mechanics/stress, or depend on other envelope tethers. This is not a judgment that lamins lack regulatory function.",
  "limitations": "60 primary reports with 8 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}