# Nuclear Lamina as Global Regulator

Lamins help organize genomes and regulate genes in defined settings; peripheral contact is not a universal gene-off switch, and global lamina-driven enzymatic silencing remains unestablished.

Scope-matched aggregation is fixed to global SC4 and yields Γ. SC2 has mapped context-specific Ε support, while SC1 remains Β and direct enzyme-recruitment necessity SC3 remains Γ. Whole-lamin deletion can change thousands of genes yet still fail to establish direct global repression: changes can be bidirectional, follow mechanics/stress, or depend on other envelope tethers. This is not a judgment that lamins lack regulatory function.

Measured boundaries are native locus/promoter, lamin isoform, redundant tether complement, differentiation state, species, stress condition and depletion duration. Cell-cycle/viability and whole-protein secondary effects remain explicit. Active peripheral genes and null contexts are retained, not retrospectively removed as irrelevant.