{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Some cancers depend strongly on a defined growth-driving gene. This review asks whether selectively withdrawing its signal regresses tumors, and separates that response from elimination of every surviving cell.",
  "implications": "The preregistered scope-matched rule reports SC1 at Η: endogenous conditional-driver and common-conduit interventions, genetic withdrawal, mechanistic resistance/rescue and baseline molecularly defined clinical trials converge on tumor-maintenance dependence across named pairs. Significant primary nonresponse, host/apoptosis dependence and persistence prevent Θ or Ω. SC2 pan-cancer one-driver generalization and SC3 residual-cell eradication remain Γ as broader mechanistic claims without matching general causal validation.",
  "limitations": "66 primary reports with 9 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}