{
  "slug": "partial-reprogramming-human-aging",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "review_date": "2026-10-14",
  "round": 2,
  "group": 3,
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "counts": { "critical": 0, "major": 1, "minor": 0, "editorial": 0 },
  "pmids_checked": 69,
  "pmids_failed": 0,
  "retractions_or_eoc_found": 0,
  "claims_spot_checked": 13,
  "validator": { "tool": "validate_review.py", "version": "2.3", "result": "PASS", "fail": 0, "warn": 0, "pass": 30, "output_file": "validator.txt" },
  "findings": [
    {
      "id": "PR-1",
      "severity": "Major",
      "type": "internal_consistency",
      "location": "AT A GLANCE, Best-supported rival",
      "original": "Reprogramming reverses causal aging processes.",
      "corrected": "Molecular reset and function are partly separable (tournament rank 1; the nominal model ranks 2).",
      "evidence": "Score card competing_models.models_evaluated marks that model M1 / is_nominal true / rank_in_tournament 2 (level Γ); the preregistration lists it first as the nominal. The rank-1 non-nominal model is M2 at Ε. The renderer used models_evaluated[0], i.e. the nominal, as the rival."
    }
  ],
  "rejected_findings": [
    "Reference years 3, 47, 66, 69 differ from PubMed by ±1 (print/issue vs e-pub) — within convention.",
    "PubMed fields dropping italicised gene names (Vitamin B12, p16High, OSK symbols) — PubMed artifact.",
    "Momentum 'Decisive work underway' carries a verified artifact (NCT07290244: recruiting, phase 1, non-randomized, unmasked, 18 estimated, primary completion 2027-05, hasResults false).",
    "Divergence 'Contested' with null implied level is permitted where no single implied level applies.",
    "Aggregation re-derived: primary-subclaim (SC2) = Γ; weakest-link and scope-matched also Γ; SC5 (Ε) is scope-restricted and cannot set the human-scoped headline.",
    "Headline Γ re-derived against the Β/Γ/Δ boundary; neither Δ nor Β is forced by the framework text.",
    "Numeric claims verified against abstracts: PMIDs 38381405, 35390271, 33268865, 29985406, 39259812, 37994989, 36277076."
  ],
  "residual_limitations": [
    "COMPETING MECHANISTIC MODELS is ordered by model ID rather than tournament rank, so the rank-1 model prints second (renderer behaviour shared across this batch).",
    "Access depth unchanged: 5 partial-body and 64 abstract/status examinations."
  ],
  "propagation": {
    "old_string": "**Best-supported rival:** Reprogramming reverses causal aging processes.",
    "new_string": "**Best-supported rival:** Molecular reset and function are partly separable (tournament rank 1; the nominal model ranks 2).",
    "note": "Package-level files (OVERVIEW.md, READER.html, MANIFEST.json, BATCH_COMPLETION.json) were not edited; the lead must propagate the banner line and this replacement where the same text appears."
  },
  "status": "Approved as revised"
}