{
  "slug": "pku-phenylalanine",
  "edition": "consensus_consistency_audit_2026-10-09 revised",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "review_date": "2026-10-14",
  "round": 2,
  "level_before": "Θ",
  "level_after": "Θ",
  "confidence_before": "High",
  "confidence_after": "High",
  "pmids_checked": 28,
  "pmids_failed": 0,
  "claims_spot_checked": 19,
  "claims_failed": 0,
  "findings_by_severity": {
    "Critical": 0,
    "Major": 0,
    "Minor": 3,
    "Editorial": 0
  },
  "findings": [
    {
      "id": "AR-1",
      "severity": "Minor",
      "regression": true,
      "type": "false_provenance",
      "location": "spliced Consensus consistency validation block, closing paragraph; consensus-addendum.md",
      "original": "Its original narrative, registered scope, source inventory, grades and any earlier approval remain historical records; the earlier approval does not certify this supplement.",
      "corrected": "Its original narrative, registered scope, source inventory and grades remain historical records. No earlier adversarial approval is attached to this case, so no earlier approval certifies this supplement.",
      "evidence": "No adversarial approval exists for this case in the pre-splice edition or anywhere in the case folder; the pass-01 'two adversarial passes by a different model' were authoring-stage red-team passes. Rescoped rather than deleted."
    },
    {
      "id": "AR-2",
      "severity": "Minor",
      "regression": true,
      "type": "false_provenance",
      "location": "spliced Consensus block, Frozen inventory paragraph; consensus-addendum.md",
      "original": "Two Consensus search results and two fetched records are retained as raw JSON in this folder.",
      "corrected": "Two Consensus search results and two fetched records are retained as raw JSON under checks/pku-phenylalanine/ in the audit root.",
      "evidence": "The four files named in consensus-validation.json.raw_paths are at consensus_consistency_audit_2026-10-09/checks/pku-phenylalanine/, not in the revised case folder."
    },
    {
      "id": "AR-3",
      "severity": "Minor",
      "regression": false,
      "type": "internal_consistency",
      "location": "Citation ledger preamble",
      "original": "All 15 numbered sources are primary research reports.",
      "corrected": "Of the 27 numbered sources, 25 are primary research reports; rows 19 and 26 are Tier B and are not primary reports (a pooled meta-analysis and a seminar), as the pass-02 note below records.",
      "evidence": "Contradicts the header 'Sources: 27 (25 Tier A)', the 27-row table beneath it and the pass-02 note at the foot of the same section. Row 19 is a systematic review/meta-analysis, row 26 a Lancet seminar."
    }
  ],
  "rejected_findings": [
    "Theta vs Eta: re-argued both ways; the untreated-phenotype exception is to penetrance of the disability threshold, not to the causal effect, and is already the named Omega blocker.",
    "Theta vs Omega: sufficiency is not deterministic and the candidate transport modifier is unvalidated; blocker correctly quoted from the framework.",
    "Independence basis: four qualifying modalities pass the v5.2 shared-failure test; pharmacological-lowering row correctly excluded.",
    "Momentum 'Mechanistic only': actively tested against the blind run's 'Decisive work underway' and rejected after a registry check of the named gene-therapy programmes (Phe endpoints only).",
    "Confidence High: rationale rests on reproducibility across modalities, not access depth; unaffected by the lead's two-step test.",
    "Stacked pass-01/pass-02 presentation with 'superseded where it concerns' pointers: deliberate, internally consistent house style.",
    "'prior H. pylori deliverables' sentence in Reviewer notes: appears in no other review in the audit, so session housekeeping rather than mis-spliced boilerplate; left as written and reported.",
    "No collective-author defect and no missing-space rendering defects anywhere in the document.",
    "Rubric 06 declined with a stated reason rather than applied literally.",
    "Print/e-pub year plus-or-minus 1 differences and PubMed title-case normalisation: rejected per convention."
  ],
  "residual_limitations": [
    "Edition is not blind and the sealed calibration band spans Eta-Theta, so it cannot discriminate between the two readings in dispute; the review states this.",
    "Most records assessed from abstracts; full or partial text read for refs 1, 8, 23, 25.",
    "The review checked status flags by PubMed publication-type search rather than Europe PMC's correction service; this reviewer independently re-checked all 27 records and found no flags."
  ],
  "validator": {
    "result": "PASS",
    "fails": 0,
    "warns": 2,
    "passes": 35,
    "detail": "Both warnings are the disclosed v5.calibration unblinded-calibration warnings; matches the review's own '0 fail / 2 disclosed warn'.",
    "pre_review_validator": "none present in case folder"
  },
  "files_changed": [
    "pku-phenylalanine.review.md",
    "consensus-addendum.md",
    "validator.txt"
  ],
  "lead_artifact_sweep": {
    "false_approval_boilerplate": "present in a different wording ('the earlier approval does not certify this supplement'); rescoped. Corpus sweep: that variant in 31 revised reviews, the circulated variant in 168.",
    "confidence_from_access_depth": "not present; band untouched",
    "best_supported_rival_renderer_bug": "not applicable; this review has no 'Best-supported rival' field",
    "reviewer_notes_consensus_contradiction": "not present; this review's notes never claim no Consensus work was performed",
    "momentum_decisive_work_underway": "not used; actively rejected with a registry check"
  },
  "consensus_questions": [
    "Has any prospectively validated modifier (brain phenylalanine transport, genotype or other) been shown to predict which untreated PAH-deficient individuals escape intellectual disability, in an independent cohort?"
  ]
}