{
 "slug": "psychedelic-microdosing-symptoms",
 "round": 2,
 "date": "2026-10-14",
 "authoring_model": "Sol 6.1",
 "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
 "canonical_path": "hsef_v53_traffic_ranks_16_20_2026-10-13\\psychedelic-microdosing-symptoms\\psychedelic-microdosing-symptoms.review.md",
 "level_before": "Γ",
 "level_after": "Γ",
 "confidence_before": "Moderate",
 "confidence_after": "Moderate",
 "role_before": "epiphenomenon",
 "role_after": "epiphenomenon",
 "counts": {
  "critical": 0,
  "major": 0,
  "minor": 5,
  "editorial": 0,
  "distinct_string_corrections": 11,
  "occurrences_replaced": 17
 },
 "pmids_checked": 64,
 "pmids_failed": 0,
 "dois_checked": 64,
 "dois_failed": 0,
 "retraction_flags": 0,
 "claims_spot_checked": 16,
 "collective_author_bug_present": false,
 "validator": {
  "tool": "validate_review.py (package-bundled v2.3)",
  "result": "PASS",
  "fail": 0,
  "warn": 0,
  "pass": 30,
  "output": "validator.txt"
 },
 "findings": [
  {
   "id": 1,
   "severity": "Minor",
   "class": "rendering",
   "location": "Deciding experiment / PROPOSED DECISIVE EXPERIMENTS / Boundary experiment (3 identical copies)",
   "changes": [
    [
     "base-equivalentLSD twiceweekly",
     "base-equivalent LSD twice weekly"
    ],
    [
     "with equalcontact/co-care",
     "with equal contact/co-care"
    ],
    [
     "follow throughwithdrawal and relapse",
     "follow through withdrawal and relapse"
    ]
   ]
  },
  {
   "id": 2,
   "severity": "Minor",
   "class": "rendering",
   "location": "AT A GLANCE / Best-supported rival",
   "changes": [
    [
     "six-week home LSD36997080",
     "six-week home LSD 36997080"
    ],
    [
     "Open-label diagnosed-MDD41202873",
     "Open-label diagnosed-MDD 41202873"
    ]
   ]
  },
  {
   "id": 3,
   "severity": "Minor",
   "class": "rendering",
   "location": "Competing models Rank 1",
   "changes": [
    [
     "from pre/postnull",
     "from pre/post null"
    ]
   ]
  },
  {
   "id": 4,
   "severity": "Minor",
   "class": "rendering",
   "location": "Competing models Rank 2",
   "changes": [
    [
     "Full-dose psychedelic andketamine treatments",
     "Full-dose psychedelic and ketamine treatments"
    ],
    [
     "ketamine dependency;active-controlled 23982301 andwithdrawal 31166571",
     "ketamine dependency; active-controlled 23982301 and withdrawal 31166571"
    ],
    [
     "establish LSDmicrodose equivalence",
     "establish LSD microdose equivalence"
    ]
   ]
  },
  {
   "id": 5,
   "severity": "Minor",
   "class": "rendering",
   "location": "Competing models Rank 3",
   "changes": [
    [
     "Direct 8-week MDD41202873",
     "Direct 8-week MDD 41202873"
    ],
    [
     "restricted 48 hour highBDI38042914 positive",
     "restricted 48-hour high-BDI 38042914 positive"
    ]
   ]
  }
 ],
 "rejected_findings": [
  "Reference #30 PMID 33591231: review prints 2022, PubMed ahead-of-print 2020; print issue is 2022;36(1) - review correct.",
  "Aggregation rule primary-subclaim with SC2 primary correctly applied; reported alternatives (weakest-link Α, scope-matched Γ) correct.",
  "Momentum 'Mechanistic only' carries required artifact; decisive trial completed not underway.",
  "Dose-unit conversions verified against stored original Methods of PMID 35106880 and PMID 40105807.",
  "No collective-author / leading-comma reference defect present.",
  "Framework-root validator v2.4 v5.lay_summary FAIL is a v5.4-only check; this review is v5.3 and the package validator passes."
 ],
 "residual_defects": [
  "Builder lost-space rendering defect recurs at ~130 further sites in the technical body; recommended fix at the generator, not in prose."
 ],
 "consensus_question": "In adults with major depressive disorder, does repeated subperceptual LSD microdosing (5-20 micrograms base, 4-12 weeks) reduce depression symptoms more than a credible active comparator in a blinded randomized trial?",
 "sha256_review_md_after": "848fc6216c610c1b52b54ab5b06c8b9b254636c6d795fda16dca85208a2e5bb1",
 "bytes_review_md_after": 138316
}