{
  "case": "rapamycin-human-healthspan",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "date": "2026-10-14",
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "pmids_checked": 55,
  "pmids_failed": 0,
  "claims_spot_checked": 12,
  "validator": "PASS (0 fail, 0 warn, 30 pass)",
  "findings": [
    {
      "id": "RAPA-1",
      "severity": "Major",
      "location": "review.md and scorecard.json throughout",
      "original": "pervasive loss of inter-word spacing, including statistical strings (e.g. 'IRR1.57,95%CI0.86-2.87,P.14', 'P.089', '85%of', 'Rapamune6mg', 'aged65-85', 'SC2Γ', 'm TOR', 'p 21', 'C57 BL/6 J')",
      "corrected": "~400 segments repaired across both artifacts; all numeric/statistical strings and high-salience sections restored; comma/semicolon spacing restored mechanically",
      "evidence": "Known rendering-defect class. Present in the score card as well as the prose, so introduced before HTML rendering. Residual glued multi-word runs remain in parts of the decisive-perturbation inventory, evidence cards and pitfalls where boundaries are not mechanically recoverable; flagged for authoring-side regeneration. No number or finding altered."
    },
    {
      "id": "RAPA-2",
      "severity": "Minor",
      "location": "scorecard final_score.confidence_rationale",
      "original": "density, heterogeneous controls and incomplete access set the confidence, not correctness",
      "corrected": "rationale rescoped to evidence density, replication and the single-trial basis of the registered functional question; access removed as an input",
      "evidence": "hsef-framework.md Confidence band: confidence reflects evidence density and reproducibility, not reviewer access. Band remains Moderate."
    },
    {
      "id": "RAPA-3",
      "severity": "Minor",
      "location": "Falsification and pitfalls; pitfalls_flagged",
      "original": "six pitfall entries unreadable due to removed spacing",
      "corrected": "spacing restored in all six entries",
      "evidence": "Same defect class as RAPA-1."
    }
  ],
  "rejected_findings": [
    "Reference years off by one versus PubMed (30468013, 23682161, 26657143, 38062873, 26463117) — print vs e-pub convention.",
    "'Best-supported rival' — names M3 with is_nominal=false and rank 1; the nominal-as-rival renderer defect is NOT present here.",
    "Kraig '28 enrolled / 25 completing ≥8 weeks' — arithmetically consistent with the abstract (25 adults, 3 withdrawals, 11+14 completers) and stated as a Methods reading.",
    "Momentum 'Mechanistic only' — correct, with a non-boilerplate artifact explanation.",
    "Role of mechanism 'epiphenomenon' — derivation step 2 correctly applied.",
    "Primary-subclaim aggregation Γ from SC2 — SC2 is scope-matched; the Ε/Δ entries are rival models, not subclaims.",
    "Pitfall 'where' fields phrased as the failure mode rather than as a guard — house-style variation in a free-text field.",
    "Collective-author rendering defect — no consortium first author in this reference list.",
    "False-approval boilerplate — string absent from this package.",
    "Empty 'DOI: .' fields and 'PMIDnot supplied' strings — none found."
  ],
  "residual_limitations": "Bounded access (3 partial-body, 52 abstract/status). Residual glued prose needs authoring-side regeneration. PEARL compounded-formulation exposure uncertainty unresolved. RAPA-EX is a 40-participant 13-week exploratory trial.",
  "approval": "Approved as revised."
}