{
  "slug": "rbp-aggregation-als-ftd",
  "edition": "2026-10-09 revised edition of hsef_v53_popularity_ranks_36_40_2026-10-08",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "date": "2026-10-14",
  "round": 2,
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "momentum_before": "Decisive work underway",
  "momentum_after": "Mechanistic only",
  "pmids_checked": 63,
  "pmids_failed": 0,
  "retractions_found": 0,
  "claims_spot_checked": 13,
  "validator": "PASS (0 fail, 1 pre-existing WARN v5.claim_form, 31 pass) using validate_review.py 2.3, this v5.3 package's validator of record; the repo-root copy is now 2.4 (v5.4) and its new mandatory lay_summary check fails every v5.3 document - a version mismatch, not a defect, and lay summaries were deliberately not retrofitted",
  "findings": [
    {
      "id": "A1",
      "severity": "Major",
      "regression": true,
      "location": "spliced 'Consensus provenance reconciliation' block in review.md and the same sentence in consensus-addendum.md",
      "issue": "False-approval boilerplate spliced in unconditionally on 2026-10-09; this case has no earlier adversarial approval",
      "original": "The earlier adversarial approval refers to its original edition; this provenance supplement is not a new independent or blinded adjudication.",
      "corrected": "No earlier adversarial approval is attached to this case: its original edition (hsef_v53_popularity_ranks_36_40_2026-10-08) post-dates the 2026-10-06 adversarial pass and was not covered by it. This provenance supplement is not a new independent or blinded adjudication.",
      "evidence": "ADVERSARIAL_REVIEW_SUMMARY_2026-10-06.md covers packages through hsef_v53_popularity_ranks_21_25_2026-10-06 only; this case's original batch is dated 2026-10-08 and carries no banner, no approval section and no sol61-original backups."
    },
    {
      "id": "A2",
      "severity": "Major",
      "regression": false,
      "location": "AT A GLANCE table; Final score M/S/D; scorecard extended_scoring_MSD.momentum",
      "issue": "Momentum 'Decisive work underway' justified by two completed publications",
      "original": "Decisive work underway",
      "corrected": "Mechanistic only (artifact rescoped)",
      "evidence": "Framework requires work actually being run that could cross the next threshold. The jacifusen series does record an ongoing efficacy trial, now named, but it lowers total FUS in familial FUS-ALS and cannot separate material state from nuclear loss of function across sporadic ALS-FTD. Momentum modifies no letter."
    },
    {
      "id": "A3",
      "severity": "Editorial",
      "regression": false,
      "location": "review.md (22 replacements) and matching scorecard strings",
      "issue": "Renderer defects in linked-notice strings and missing spaces",
      "original": "UpdateOf: PMID36747793 / ErratumIn: PMID38890465 / UpdateOf: PMIDnot supplied / by29weeks / P1 20microgram / participant1 / journal2023 / journal2018 replaces conference2017",
      "corrected": "Update of: PMID 36747793 / Erratum in: PMID 38890465 / Update of: PMID not supplied / by 29 weeks / P1 20 microgram / participant 1 / journal 2023 / journal 2018 replaces conference 2017",
      "evidence": "Known reference-builder defects including the 'PMIDnot supplied' string named in the brief. No numeral, dose or PMID value altered."
    },
    {
      "id": "A4",
      "severity": "Minor",
      "regression": false,
      "location": "scorecard.json final_score.confidence_rationale (3 copies of the string)",
      "issue": "Confidence band justified partly by reviewer access depth",
      "original": "63 primary reports with 9 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness.",
      "corrected": "Multiple independent studies across 63 primary reports with real replication in some arms, but coupled interventions that change nuclear function and mutant protein together, overexpression and forced-assembly models, and shared mouse lines standing in for independent replication remain; evidence density and reproducibility set the band, not reviewer access or correctness.",
      "evidence": "Lead two-step policy applied: access struck, band re-derived. Band stands at Moderate because the review documents real evidence-quality reservations, so the High text is not reached."
    },
    {
      "id": "A5",
      "severity": "Editorial",
      "regression": false,
      "location": "REFERENCES entry 24 (PMID 35075293)",
      "issue": "Reference and prose disagreed silently on the first author's surname",
      "original": "Reference prints 'Korben VA'; prose says 'Korobeynikov'. No note.",
      "corrected": "Note added at the reference recording the discrepancy; neither form altered.",
      "evidence": "PubMed renders the 2022 record's first author as 'Korben VA'. Reference 49 (PMID 40414239) lists 'Korobeynikov VA' with the same initials, senior author and centre, so the two forms very probably denote one person and the 2022 record is probably the lossy one - the same field-corruption pattern seen with dropped italics and empty CollectiveName objects. Not verified, and an author's name is not asserted against the indexed record on inference, so both forms stand and the discrepancy is now visible rather than silent. Lead ruling, 2026-10-14."
    }
  ],
  "rejected_findings": [
    "Reviewer-notes contradiction (the known Oct 9 splice artifact) does NOT apply here: the preserved REVIEWER NOTES make no claim that Consensus work was absent, and the review carries its own Consensus source log and reconciliation section. Only the approval sentence was false (A1).",
    "Scope-matched aggregation applied correctly as 'highest subclaim whose scope matches', not 'highest subclaim': SC5 (broad sporadic ALS-FTD) Γ sets the headline while SC2 Ζ and SC3 Ε are explicitly scope-restricted and reported separately. Weakest-link Β and primary-subclaim Γ also correct.",
    "'Best-supported rival' renderer bug: models_evaluated[0] is rank 1 with is_nominal false; the nominal is rank 4. Prose names the true rival.",
    "29-week survival figure for PMID 31332509 verified against the locally held full text ('median survival increase of 29 weeks (66%)', 44 to 73 weeks, blinded assessment, two cohorts).",
    "PMID 40414239 (12 participants, CSF NfL down up to 82.8% at 6 months, one objective functional recovery, most declining) and PMID 20071528 (inclusions not necessary for toxicity; cytoplasmic TDP-43 a strong independent predictor) both match the review.",
    "Headline Γ argued up to Δ and down to Β; both rejected. The FUS allele-reversal and FUS-lowering experiments remove mutant protein and restore nuclear function together, so they do not perturb the registered aggregate-specific arm.",
    "No collective-author/leading-comma references and no empty DOI fields.",
    "Counts 63/69/69/0 consistent across banner, provenance_header and verification_summary; the revision altered no count.",
    "v5.claim_form 'phenomenon' WARN is pre-existing and falls under the rejected-finding convention (the registered claim states presence plus consequence)."
  ],
  "residual_limitations": "54 of 63 sources examined at abstract/status depth; five linked errata have unexamined correction details and three linked notices carry no supplied PMID.",
  "approval": "Approved as revised — Claude Opus 5.5 (Anthropic), 2026-10-14."
}