{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "TDP-43 and FUS help regulate RNA. This review separates the effects of losing their normal nuclear functions, moving them into the cytoplasm and forming visible aggregates in ALS and frontotemporal degeneration.",
  "implications": "The preregistered scope-matched gate SC5 is Γ. Nuclear splicing failure has convergent causal and functional rescue evidence (SC2 Ζ), and physiological mutant-FUS toxicity is context-valid (SC3 Ε). Neither establishes selective macroscopic-aggregate toxicity or principal dual-arm causation across sporadic ALS–FTD. No narrow success silently replaces that broad gate.",
  "limitations": "63 primary reports with 9 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}