Selected publication milestones, not an exhaustive history or discovery priority claim.
2009 — RNA depletion establishes defined paraspeckle architectural dependence. Original PMID19188602.
2011 — Mouse genetic loss removes local bodies with baseline tissue boundaries. Original PMID21444682.
2014 — Firre locus and protein perturbations test selected trans-site organization. Original PMID24463464.
2017 — SAF-A RNA-binding/oligomer rescue links structure to gene-rich chromatin. Original PMID28622508.
2018 — HNRNPU perturbation changes broader cellular genome architecture. Original PMID29273625.
2021 — Polymerase-retaining versus releasing inhibition tests euchromatin microphases. Original PMID33649325.
2021 — Repeat-rich RNA scaffold extraction and physical redistribution strengthen material hypotheses. Original PMID34320406.
2025 — Final SAP-domain study separates dynamic nuclear and XIST functions. Original PMID40493679.
Develop intact-cell RNA-selective structure perturbations that preserve polymerase attachment and RNA/protein chemistry.
Measure load-bearing rheology independently of RNA occupancy, chromatin marks or extraction insolubility.
Separate seconds/minutes structural responses from later splicing, replication stress and cell-cycle redistribution.
Map gene-density, compartment and developmental boundaries before outcomes rather than define scaffold-active responders.
Reconcile short polymerase-retaining inhibition with longer RNA depletion and cell-type-specific drug responses.
Test RNA rescue without restoring transcriptional work or the deleted DNA regulatory element.
Audit linked correction bodies and full supplements; unavailable public body is an access limitation, not a negative experiment.
Prespecify several intact interphase cell states and gene-rich/poor compartments; reversibly disrupt nascent RNA material interactions without terminating polymerase or changing RNA-protein abundance, assay chromatin mechanics and compaction with orthogonal live methods, and rescue architecture with endogenous-level structural RNA while transcriptional work remains controlled.