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    "rationale": "The preregistered scope-matched SC3 gate returns Ε: causal validity with explicit context limits. Driver identification reaches Ζ and defined initiation/maintenance dependencies reach Η through endogenous autochthonous genetics, restoration/rechallenge, human genomic natural history and genotype-selected hard clinical outcomes. The set is not re-capped by culture or xenograft limitations. Broad primacy requires a representative comparison of mutation, tissue and cell-state causation across initiation, maintenance and relapse; that burden is not established by genetic relevance alone. Benign driver clones challenge sufficiency, not the strong causal genetic evidence."
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    "rationale": "The preregistered scope-matched SC3 gate returns Ε: causal validity with explicit context limits. Driver identification reaches Ζ and defined initiation/maintenance dependencies reach Η through endogenous autochthonous genetics, restoration/rechallenge, human genomic natural history and genotype-selected hard clinical outcomes. The set is not re-capped by culture or xenograft limitations. Broad primacy requires a representative comparison of mutation, tissue and cell-state causation across initiation, maintenance and relapse; that burden is not established by genetic relevance alone. Benign driver clones challenge sufficiency, not the strong causal genetic evidence."
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}
