Cutoff: 9 October 2026. Consensus supports discovery and checks of specific source aspects; it is not a primary study, a full-paper audit or a causal probability meter.
The original alpha-globin Results agree with Consensus's targeted summary of apparent additive contributions and dominant R1/R2 elements. Single deletions and two informative double deletions do not exhaust all interactions. The broad provider matrix incorrectly reported no additive-deletion papers despite this experimental paper. Original PMID27376235. Access: full_text_partial.
Original allele-specific deletion Results confirm a dispensable called Med13l super-enhancer and strong non-SE Lifr/Jarid2 regions. Consensus's targeted summary accurately identifies functional heterogeneity and the transcription endpoint. Selected comparators are not a complete panel matched on signal, length, element number and promoter compatibility. Original PMID27895109. Access: full_text_partial.
The original tested enhancer pairs were additive, and combined TF-site loss at the proximal element prevented other components from assembling. Consensus's targeted answer agrees with this distinction. The endpoint is milk-gene expression and stage-dependent regulatory assembly, not conversion of the whole mammary lineage identity. Original PMID27376239. Access: full_text_partial.
Consensus could not retrieve Blayney's exact paper, whose canonical final publication is 2023. Original reconstruction shows R2 alone produces much less globin than predicted from its single deletion, with position-dependent interchangeable facilitators and matched erythroid populations. This is genuine local functional cooperation and rejects an all-additive counterclaim; it does not establish a qualitatively distinct SE class or an erythroid identity switch. Original PMID38101409. Access: full_text_partial.
Consensus had no original Results for the exact Huang paper. The original hub deletion and nonhub/CTCF-site contrasts show stronger effects of hub removal on selected output and neighboring chromatin marks in K562 cells. It is a native hierarchy experiment in transformed cells, not class-wide identity mediation against fully matched conventional clusters. Original PMID29507293. Access: full_text_partial.
Consensus could not retrieve the exact orientation paper. Original Results show that inverting the cluster changes globin and upstream gene output while erythroid differentiation is retained; isolated R2 inversion and boundary controls narrow alternatives. A linked correction is recorded in original metadata, but its detailed body was not examined. This comparison must not imply that the correction itself was validated. Original PMID39863595. Access: full_text_partial.
Consensus had no original exact-paper text. Original allele-specific motif and CTCF-insertion Results separate large transcriptional effects from distributed architecture and show moderate contact reduction without a detected expression change. Residual contacts remain; snapshot active-site fractions do not directly measure live burst frequency. Original PMID35710138. Access: full_text_partial.
Consensus could not assess the exact Crump paper. Original short-treatment nascent RNA and Capture-C Results show transcriptional changes while most enhancer-promoter contacts remain, after BET inhibitor and degrader treatments. Drug/protein pleiotropy and nonspecific hexanediol effects prevent interpreting this as a selective SE-phase intervention. Original PMID33431820. Access: full_text_partial.
Original Vsx2-region deletion removes bipolar cells across three mouse sublines, with single-cell, histological, ultrastructural and visual-function readouts. This strengthens the local identity evidence beyond the provider's mainly expression-based coverage. It does not by itself establish disproportionate causal control by a qualitatively distinct class compared with equally strong conventional enhancers. Original PMID31493975. Access: full_text_partial.
Consensus was used to identify literature and cross-check specific claims about design, endpoints, scope and research gaps. Those aspects were checked against original primary abstracts/status records and selected original Methods/Results passages. Consensus output was not treated as original full text. Provider search omissions are not evidence that a study does not exist. Source access and examination receipts are retained. Scite use or monthly unavailability is recorded per case; provider citation counts do not change causal grades.