{
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  "status": "completed_original_source_reconciliation",
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  "query_record_note": "Exact visible question/response retained privately in raw browser receipt.",
  "primary_comparison_count": 9,
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    {
      "pmid": "27376235",
      "doi": "10.1038/ng.3605",
      "source_type": "primary study report",
      "study_group": "PMID27376235",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Native apparent additivity is scoped to the tested allele series",
      "result_comparison": "The original alpha-globin Results agree with Consensus's targeted summary of apparent additive contributions and dominant R1/R2 elements. Single deletions and two informative double deletions do not exhaust all interactions. The broad provider matrix incorrectly reported no additive-deletion papers despite this experimental paper.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/27376235/",
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    {
      "pmid": "27895109",
      "doi": "10.1101/gr.210930.116",
      "source_type": "primary study report",
      "study_group": "PMID27895109",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Called super-enhancers and strong conventional comparators",
      "result_comparison": "Original allele-specific deletion Results confirm a dispensable called Med13l super-enhancer and strong non-SE Lifr/Jarid2 regions. Consensus's targeted summary accurately identifies functional heterogeneity and the transcription endpoint. Selected comparators are not a complete panel matched on signal, length, element number and promoter compatibility.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/27895109/",
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    {
      "pmid": "27376239",
      "doi": "10.1038/ng.3606",
      "source_type": "primary study report",
      "study_group": "PMID27376239",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Wap hierarchy does not reduce to either universal synergy or universal addition",
      "result_comparison": "The original tested enhancer pairs were additive, and combined TF-site loss at the proximal element prevented other components from assembling. Consensus's targeted answer agrees with this distinction. The endpoint is milk-gene expression and stage-dependent regulatory assembly, not conversion of the whole mammary lineage identity.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/27376239/",
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    {
      "pmid": "38101409",
      "doi": "10.1016/j.cell.2023.11.030",
      "source_type": "primary study report",
      "study_group": "PMID38101409",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Missing native reconstruction changes the additive interpretation",
      "result_comparison": "Consensus could not retrieve Blayney's exact paper, whose canonical final publication is 2023. Original reconstruction shows R2 alone produces much less globin than predicted from its single deletion, with position-dependent interchangeable facilitators and matched erythroid populations. This is genuine local functional cooperation and rejects an all-additive counterclaim; it does not establish a qualitatively distinct SE class or an erythroid identity switch.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/38101409/",
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    {
      "pmid": "29507293",
      "doi": "10.1038/s41467-018-03279-9",
      "source_type": "primary study report",
      "study_group": "PMID29507293",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Provider absence does not erase hub perturbation evidence",
      "result_comparison": "Consensus had no original Results for the exact Huang paper. The original hub deletion and nonhub/CTCF-site contrasts show stronger effects of hub removal on selected output and neighboring chromatin marks in K562 cells. It is a native hierarchy experiment in transformed cells, not class-wide identity mediation against fully matched conventional clusters.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/29507293/",
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    {
      "pmid": "39863595",
      "doi": "10.1038/s41467-025-56380-1",
      "source_type": "primary study report",
      "study_group": "PMID39863595",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Cluster orientation and correction limits",
      "result_comparison": "Consensus could not retrieve the exact orientation paper. Original Results show that inverting the cluster changes globin and upstream gene output while erythroid differentiation is retained; isolated R2 inversion and boundary controls narrow alternatives. A linked correction is recorded in original metadata, but its detailed body was not examined. This comparison must not imply that the correction itself was validated.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/39863595/",
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    {
      "pmid": "35710138",
      "doi": "10.1101/gad.349489.122",
      "source_type": "primary study report",
      "study_group": "PMID35710138",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Native Sox2 chemistry and architecture can separate",
      "result_comparison": "Consensus had no original exact-paper text. Original allele-specific motif and CTCF-insertion Results separate large transcriptional effects from distributed architecture and show moderate contact reduction without a detected expression change. Residual contacts remain; snapshot active-site fractions do not directly measure live burst frequency.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/35710138/",
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    {
      "pmid": "33431820",
      "doi": "10.1038/s41467-020-20400-z",
      "source_type": "primary study report",
      "study_group": "PMID33431820",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Drug effects on output differ from contact maintenance",
      "result_comparison": "Consensus could not assess the exact Crump paper. Original short-treatment nascent RNA and Capture-C Results show transcriptional changes while most enhancer-promoter contacts remain, after BET inhibitor and degrader treatments. Drug/protein pleiotropy and nonspecific hexanediol effects prevent interpreting this as a selective SE-phase intervention.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/33431820/",
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    {
      "pmid": "31493975",
      "doi": "10.1016/j.neuron.2019.08.002",
      "source_type": "primary study report",
      "study_group": "PMID31493975",
      "access_depth": "full_text_partial",
      "consensus_aspect": "A genuine developmental cell-identity positive",
      "result_comparison": "Original Vsx2-region deletion removes bipolar cells across three mouse sublines, with single-cell, histological, ultrastructural and visual-function readouts. This strengthens the local identity evidence beyond the provider's mainly expression-based coverage. It does not by itself establish disproportionate causal control by a qualitatively distinct class compared with equally strong conventional enhancers.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/31493975/",
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  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T20:10:07.324629+00:00",
  "conclusion": "Endpoint hierarchy, experimental scope and original-source limits determine the evidence cards; provider wording does not override them."
}