{
  "completed": true,
  "status": "completed_original_source_reconciliation",
  "provider_mode": "Consensus Pro signed-in browser; observed response and citation-link mappings",
  "queries": [
    "https://consensus.app/search/telomere-attrition-aging-mechanisms/qRW9GXPJToOrGTAassMyGQ/"
  ],
  "query_record_note": "Observed thread URL and visible request/response in raw receipt; no unobserved query payload reconstructed.",
  "primary_comparison_count": 4,
  "primary_comparisons": [
    {
      "pmid": "21113150",
      "doi": "10.1038/nature09603",
      "source_type": "primary study report",
      "study_group": "PMID21113150",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Telomerase restoration can reverse degeneration.",
      "result_comparison": "Original body restricts this rescue to late-generation telomerase-deficient adult male mice, with normal G0 controls. It does not demonstrate telomere primacy in ordinary human aging.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/21113150/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\examinations\\resumption-0-14-1100.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\body-presentation-receipts\\21113150-s0-p0.json",
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\body-presentation-receipts\\21113150-s3-p4-8.json"
      ]
    },
    {
      "pmid": "22585399",
      "doi": "10.1002/emmm.201200245",
      "source_type": "primary study report",
      "study_group": "PMID22585399",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Adult telomerase intervention can extend lifespan.",
      "result_comparison": "Original mouse Methods and Results show ectopic AAV-TERT intervention, small experimental groups and an inactive-TERT control. This supports a restricted model effect; it does not separate every telomere and noncanonical TERT effect.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/22585399/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\examinations\\resumption-33-51-1200.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\body-presentation-receipts\\22585399-s1-p19.json",
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\body-presentation-receipts\\22585399-s3-p0.json"
      ]
    },
    {
      "pmid": "31444995",
      "doi": "10.1111/acel.13017",
      "source_type": "primary study report",
      "study_group": "PMID31444995",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Human genetics links telomeres to age-related outcomes.",
      "result_comparison": "Original body distinguishes lower coronary risk from higher cancer risk and weak or null functional/lifespan outcomes. Directional trade-offs are retained rather than equating longer telomeres with uniformly healthier aging.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/31444995/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\examinations\\resumption-14-33-850.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\body-presentation-receipts\\31444995-s3-p3-4-5.json"
      ]
    },
    {
      "pmid": "26950204",
      "doi": "10.1089/rej.2015.1793",
      "source_type": "primary study report",
      "study_group": "PMID26950204",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Telomerase activators offer a human intervention lead.",
      "result_comparison": "Original trial body defines the primary endpoint as leukocyte telomere length, with a low-dose signal and nonsignificant high-dose comparison. A biomarker response does not establish extended human healthspan.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/26950204/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\examinations\\resumption-33-51-1200.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\body-presentation-receipts\\26950204-s1-p0-1.json"
      ]
    }
  ],
  "grade_changed": false,
  "grade_change_note": "Comparison does not introduce an independently blinded regrade; bounded case adjudication remains source-based.",
  "raw_receipts": [
    {
      "path": "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\telomere-shortening\\consensus-browser-2026-10-11.json",
      "sha256": "322890b1a0efe7e311b5cf37aaebfadbc4807e77fafa70229bc3ed92bc99d5c4"
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  ],
  "independent_blinded_audit": false,
  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T02:11:32.915157+00:00",
  "conclusion": "Specific qualifiers and endpoint hierarchy above are retained in the evidence cards; AI wording does not override the original sources."
}