{
  "slug": "trained-immunity",
  "round": 2,
  "date": "2026-10-14",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "canonical": "consensus_consistency_audit_2026-10-09\\revised\\trained-immunity\\trained-immunity.review.md",
  "level_before": "Ε",
  "level_after": "Ε",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "confidence_band_rederived": true,
  "approval": "Approved as revised",
  "pmids_checked": 63,
  "pmids_failed": 0,
  "retractions_found": 0,
  "claims_spot_checked": 13,
  "validator": {"tool": "validate_review.py", "version": "2.3", "ok": true, "FAIL": 0, "WARN": 1, "PASS": 31},
  "counts": {"critical": 0, "major": 2, "minor": 3, "editorial": 1},
  "findings": [
    {
      "id": "TI-1",
      "severity": "Major",
      "category": "false provenance / spliced sentence",
      "location": "Consensus provenance reconciliation block",
      "original": "The earlier adversarial approval refers to its original edition; this provenance supplement is not a new independent or blinded adjudication.",
      "corrected": "No earlier adversarial approval exists for any edition of this review; this provenance supplement is not an independent or blinded adjudication.",
      "evidence": "No edition of this review carries an ADVERSARIAL REVIEW AND APPROVAL section or approval line; the 2026-10-06 pass covered 30 other slugs."
    },
    {
      "id": "TI-2",
      "severity": "Minor",
      "category": "rendering defect / unverifiable status flag",
      "location": "Evidence card [3] Access/status line",
      "original": "ErratumIn: PMIDnot supplied.",
      "corrected": "Correction screen: no erratum, corrigendum or retraction record is indexed in PubMed for this report; status_checked_on 2026-10-14.",
      "evidence": "PubMed holds no correction record for PMID 25258083 (searched by author, journal, title, publication type)."
    },
    {
      "id": "TI-3",
      "severity": "Minor",
      "category": "dependent prose on TI-2",
      "location": "Decisive-perturbation item [3]; evidence card [3]; RESEARCH TIMELINE 2014 row",
      "original": "linked author correction noted / linked correction",
      "corrected": "removed; timeline row reads 'no indexed correction record'",
      "evidence": "Same as TI-2."
    },
    {
      "id": "TI-4",
      "severity": "Minor",
      "category": "unspecific correction claim",
      "location": "KNOWLEDGE GAPS, correction-resolution item",
      "original": "Resolve linked correction details for de Laval, HIF-1α and microbiome/BCG reports ...",
      "corrected": "de Laval errata PMID 32386557 and PMID 36608675 and gut-lung Author Correction PMID 37161093 named; HIF-1α claim withdrawn",
      "evidence": "All three named corrections verified against PubMed and attach to the correct parents; the HIF-1α one does not exist."
    },
    {
      "id": "TI-5",
      "severity": "Major",
      "category": "confidence band justified by reviewer access depth",
      "location": "AT A GLANCE (new Confidence basis paragraph); final_score.confidence_rationale and two mirrored copies",
      "original": "63 primary reports with 8 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness.",
      "corrected": "Rationale grounded in evidence density and reproducibility, with reviewer access depth explicitly excluded as a determinant.",
      "evidence": "Lead policy on confidence bands; hsef-framework.md section Confidence band. Two-step test applied: access depth was not the only basis, the review records substantive evidence-quality concerns, so Moderate stands."
    },
    {
      "id": "TI-E1",
      "severity": "Editorial",
      "category": "spelling",
      "location": "RESEARCH TIMELINE, 2018 mevalonate row",
      "original": "Constitututive",
      "corrected": "Constitutive",
      "evidence": "Spelling."
    }
  ],
  "rejected_findings": [
    "Best-supported rival renderer defect: rank 1 entry is is_nominal false; defect absent.",
    "Three references with print vs e-pub year differing by one (Domínguez-Andrés, Lechner, Jensen) - standing convention.",
    "Gaps at [4] and [30] in the decisive-perturbation inventory - those ledger rows carry no discriminating contrast; 61 items, tally 61.",
    "Inline PMID22901542 token form - systematic house token, not a dropped intra-word space.",
    "v5.claim_form 'phenomenon' warning - standing convention.",
    "Scope-matched aggregation misread - not the declared rule and headline not raised above it.",
    "REVIEWER NOTES vs spliced Consensus section - no contradiction; notes record the Consensus work performed.",
    "Momentum already 'Mechanistic only'; no completed-work artifact supporting 'Decisive work underway'.",
    "Collective authors - none in this reference list; no leading-comma defect."
  ],
  "residual_limitations": "Access depth unchanged (8 partial-body, 55 abstract/status; no complete-paper or supplement audit). Cirovic 15 vs 5 at day 90, Mills 18-week endpoint and preserved recipient lineage proportions rest on partial-body reading and could not be re-verified from abstracts; not contradicted.",
  "changed_files": [
    {"path": "trained-immunity.review.md", "sha256": "d626947975a3be372047863755175bc3fb182c0ec40ca69c5fdf736edc340f51", "bytes": 126836},
    {"path": "trained-immunity.scorecard.json", "sha256": "dd8a7ff4945f92e1f620837a3a951090091268133d8eeb7a84db5093c69efff4", "bytes": 361198},
    {"path": "SHA256.txt", "sha256": null, "bytes": null, "note": "regenerated from the two files above"},
    {"path": "validation-report.json", "sha256": null, "bytes": null, "note": "re-run, ok=true"}
  ],
  "propagate_to": [],
  "divergent_copies_not_touched": [
    "hsef_v53_popularity_ranks_26_30_2026-10-07\\trained-immunity\\trained-immunity.review.md"
  ],
  "consensus_questions": [
    "In published purified long-term-HSC transfer experiments, has any study quantified residual original inducer (labelled ligand or molecular assay) in donor cells at the time of transfer, rather than inferring clearance from elapsed time?"
  ]
}