{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Preregistered primary-subclaim aggregation uses SC3 and returns Ε, context-dependent causality, with Moderate confidence. Purified post-resolution and long-term donor-cell transfer support conditional intrinsic persistence without continued original tissue exposure. Complete ligand exclusion and independence from all ongoing signaling are not demonstrated; normal homeostatic maintenance is compatible with cell-intrinsic memory. The strict universal signal/antigen-free extension remains Γ. Weakest-link sensitivity is Γ because histone-carrier specificity and human clinical mediation remain unresolved; scope-matched primary sensitivity is Ε. The final letter does not certify the full conjunctive mechanism or universal clinical protection.",
  "implications": "Preregistered primary-subclaim aggregation uses SC3 and returns Ε, context-dependent causality, with Moderate confidence. Purified post-resolution and long-term donor-cell transfer support conditional intrinsic persistence without continued original tissue exposure. Complete ligand exclusion and independence from all ongoing signaling are not demonstrated; normal homeostatic maintenance is compatible with cell-intrinsic memory. The strict universal signal/antigen-free extension remains Γ. Weakest-link sensitivity is Γ because histone-carrier specificity and human clinical mediation remain unresolved; scope-matched primary sensitivity is Ε. The final letter does not certify the full conjunctive mechanism or universal clinical protection.",
  "limitations": "63 primary reports with 8 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}