{
  "slug": "transcriptional-condensates",
  "canonical": "consensus_consistency_audit_2026-10-09\\revised\\transcriptional-condensates\\transcriptional-condensates.review.md",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "date": "2026-10-14",
  "level_before": {
    "hsef_level": "Γ",
    "confidence": "Moderate",
    "momentum": "Decisive work underway"
  },
  "level_after": {
    "hsef_level": "Γ",
    "confidence": "Moderate",
    "momentum": "Mechanistic only"
  },
  "level_changed": false,
  "pmids_checked": 64,
  "pmids_failed": 0,
  "retractions_or_eocs": 0,
  "claims_spot_checked": 12,
  "claims_contradicted": 0,
  "validator": "PASS under validator 2.3 (version of record): 0 fail, 1 warn, 31 pass. Validator 2.4 reports 1 FAIL for the v5.4-only lay_summary check, identical on the pre-edit original.",
  "counts": {
    "Critical": 0,
    "Major": 1,
    "Minor": 4,
    "Editorial": 0
  },
  "findings": [
    {
      "id": "C1",
      "severity": "Major",
      "location": "AT A GLANCE table; Final score, causal direction and M/S/D; scorecard extended_scoring_MSD.momentum",
      "original": "Momentum: Decisive work underway. Named recent primary perturbation studies in this corpus test mechanistic or functional boundaries; no claim of a presently recruiting trial is made.",
      "corrected": "Momentum: Mechanistic only, with an artifact naming PMID 40680734, 40614721 and 42417395 and stating that none supplies the matched state-only endogenous contrast the Delta threshold requires",
      "evidence": "Framework momentum table and its required artifact; the recorded justification named no study, and the review's own Delta requirement is a reversible endogenous state-selective perturbation with matched occupancy, abundance and cofactor affinity. Momentum modifies no letter."
    },
    {
      "id": "C2",
      "severity": "Minor",
      "location": "evidence and causal interpretation, falsification section, M/S/D derivation, research timeline, reviewer notes, evidence cards",
      "original": "numerals and units fused to the preceding word (of197.5±71.9nM, near200nM, report99 genes, at least1.5-fold, with88 up and11 down, approximately60nm, mean94nm, about34 dissolutions, Both1,6 and2,5, Chong2018, The2026, preprint39131356, Step1-Step5, mislabeled5.4, Consensus2Pro/0Deep/0API, cutoff2026-10-08 with examinationOct9UTC)",
      "corrected": "spaces restored; 24 edits; no value, direction or claim altered",
      "evidence": "Round-2 brief, known upstream defect 4"
    },
    {
      "id": "C3",
      "severity": "Minor",
      "location": "Final score, causal direction and M/S/D; scorecard extended_scoring_MSD.divergence",
      "original": "Divergence: Contested; no single implied-level arithmetic.",
      "corrected": "Contested verdict retained with its required artifact naming the two framings",
      "evidence": "hsef-framework.md Divergence required artifact"
    },
    {
      "id": "C4",
      "severity": "Minor",
      "location": "Consensus provenance reconciliation block; consensus-addendum.md",
      "original": "The earlier adversarial approval refers to its original edition",
      "corrected": "rescoped to state that no earlier adversarial approval is attached to this case",
      "evidence": "the earlier edition carries no adversarial banner and no approval section; clause spliced unconditionally by the 2026-10-09 integration script"
    },
    {
      "id": "C5",
      "severity": "Minor",
      "location": "score card final_score.confidence_rationale",
      "original": "density, heterogeneous controls and incomplete access set the confidence, not correctness.",
      "corrected": "access depth dropped as a determinant; High-band re-test recorded; band holds at Moderate",
      "evidence": "framework Confidence band text"
    }
  ],
  "rejected_findings": [
    "Gamma rather than Delta for SC2 - the review reports the MYOCD paper's own 'condensate formation is required' conclusion accurately and adjudicates it against that paper's CDT1 control; this is the boundary check working as designed",
    "Weakest-link aggregation - declared before scoring, applied as written, both alternatives reported; the round-2 aggregation misread is not present",
    "Steelman order and named blocker - compliant (Delta before Beta, blocker named)",
    "Role of mechanism 'reinforcing / stabilizing factor' - derived through the numbered direction steps",
    "Stability 'Stable' - no pending result named",
    "Bare inline PMID numbers - house style",
    "v5.claim_form phenomenon warning - rejected-finding convention for this round",
    "v5.lay_summary FAIL under validator 2.4 - v5.4-only requirement, pre-existing on the original, package validates under 2.3",
    "Revision regression check - the revised edition adds only the dated Consensus provenance block relative to the earlier edition and introduces no error",
    "Confidence band re-tested against the High text after removing access depth: single-laboratory engineered and knock-in systems with contested interpretation, shared A673 labels and a shared early-imaging platform make this the Moderate text; band holds",
    "Coordinator-flagged reviewer-notes contradiction: not present; the review carries an affirmative METHODS AND CONSENSUS CONTRIBUTION section with provider query counts",
    "Best-supported rival renderer defect: models_evaluated[0] here is M2, is_nominal false, rank 1, with the nominal at rank 5; the prose names the rival correctly"
  ],
  "residual_limitations": "Ten partial-body and 54 abstract/status examinations. Body-level figures absent from the abstracts (197.5 and 131.6 nM MYOCD concentrations; 99 genes with 88 up and 11 down; 60 nm and 94 nm hub diameters; about 34 dissolutions per second) were checked for internal consistency and against bounding abstract statements only. Two linked errata remain at metadata level by the review's own disclosure.",
  "files_changed": [
    "transcriptional-condensates.review.md",
    "transcriptional-condensates.scorecard.json",
    "SHA256.txt",
    "validator-adversarial-2026-10-14.txt (new)",
    "ADVERSARIAL_REVIEW.md (new)",
    "adversarial-findings.json (new)"
  ],
  "propagated_to": [],
  "divergent_copies": [
    "hsef_v53_popularity_ranks_41_45_2026-10-08\\transcriptional-condensates\\transcriptional-condensates.review.md (earlier edition, left untouched)"
  ],
  "coordinator_round2_artifact_checks": {
    "false_approval_boilerplate": "corrected",
    "confidence_set_from_access_depth": "corrected; band re-tested against the High text and held at Moderate",
    "best_supported_rival_renderer_bug": "checked; models_evaluated[0] is a non-nominal rank-1 model, prose correct",
    "reviewer_notes_contradiction": "not present"
  }
}