{
  "slug": "tumor-microenvironment-primacy",
  "canonical": "consensus_consistency_audit_2026-10-09\\revised\\tumor-microenvironment-primacy\\tumor-microenvironment-primacy.review.md",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "date": "2026-10-14",
  "level_before": {
    "hsef_level": "Γ",
    "confidence": "Moderate",
    "momentum": "Decisive work underway"
  },
  "level_after": {
    "hsef_level": "Γ",
    "confidence": "Moderate",
    "momentum": "Mechanistic only"
  },
  "level_changed": false,
  "pmids_checked": 64,
  "pmids_failed": 0,
  "retractions_or_eocs": "1 expression of concern (PMID 26524530), already disclosed by the review and excluded from load-bearing evidence",
  "claims_spot_checked": 14,
  "claims_contradicted": 0,
  "validator": "PASS under validator 2.3 (version of record): 0 fail, 1 warn, 31 pass. Validator 2.4 reports 1 FAIL for the v5.4-only lay_summary check, identical on the pre-edit original.",
  "counts": {
    "Critical": 0,
    "Major": 1,
    "Minor": 5,
    "Editorial": 2
  },
  "findings": [
    {
      "id": "B1",
      "severity": "Major",
      "location": "AT A GLANCE table; Final score, causal direction and M/S/D; scorecard extended_scoring_MSD.momentum",
      "original": "Momentum: Decisive work underway",
      "corrected": "Momentum: Mechanistic only, with the artifact extended to name the boundary check the cited work does not address",
      "evidence": "Framework momentum table: 'Decisive work underway' requires someone running an experiment that could cross the next threshold; the recorded artifact says the named work tests mechanisms and that no recruiting trial or pending result is asserted. Momentum modifies no letter."
    },
    {
      "id": "B2",
      "severity": "Minor",
      "location": "decisive-perturbation inventory, falsification section, research timeline, evidence cards",
      "original": "statistic labels and words fused to numerals (HR0.92, CI0.71-1.19, p0.53, OS15.7 versus16.1, PFS7.1, phase2, control47, from13 to63, erratum27124464, erratum31442371, correction30291359, August2026, Hoshino2015, Online2024)",
      "corrected": "spaces restored; 63 edits; every trial number touched re-verified against its abstract first",
      "evidence": "Round-2 brief, known upstream defect 4"
    },
    {
      "id": "B3",
      "severity": "Minor",
      "location": "evidence cards [12], [28], [40], [46]",
      "original": "ErratumIn: PMIDnot supplied.",
      "corrected": "Erratum in: PMID not supplied.",
      "evidence": "Round-2 brief, known upstream defect 4; the sibling card with an available identifier already prints 'Erratum in: PMID27124464'"
    },
    {
      "id": "B4",
      "severity": "Editorial",
      "location": "REFERENCES item 1",
      "original": "DOI: .",
      "corrected": "DOI: none indexed.",
      "evidence": "PubMed record for PMID 10519415 carries no DOI"
    },
    {
      "id": "B5",
      "severity": "Editorial",
      "location": "Evidence and causal interpretation",
      "original": "reproduces a adverse phenotype",
      "corrected": "reproduces an adverse phenotype",
      "evidence": "grammar"
    },
    {
      "id": "B6",
      "severity": "Minor",
      "location": "Final score, causal direction and M/S/D; scorecard extended_scoring_MSD.divergence",
      "original": "Divergence: Contested; no single implied-level arithmetic.",
      "corrected": "Contested verdict retained with its required artifact naming the two framings",
      "evidence": "hsef-framework.md Divergence required artifact"
    },
    {
      "id": "B7",
      "severity": "Minor",
      "location": "Consensus provenance reconciliation block; consensus-addendum.md",
      "original": "The earlier adversarial approval refers to its original edition",
      "corrected": "rescoped to state that no earlier adversarial approval is attached to this case",
      "evidence": "the earlier edition of this review carries no adversarial banner and no approval section; the clause was spliced unconditionally by the 2026-10-09 integration script, so the misstatement is revision-introduced"
    },
    {
      "id": "B8",
      "severity": "Minor",
      "location": "score card final_score.confidence_rationale",
      "original": "density, heterogeneous controls and incomplete access set the confidence, not correctness.",
      "corrected": "access depth dropped as a determinant; High-band re-test recorded; band holds at Moderate",
      "evidence": "framework Confidence band text"
    }
  ],
  "rejected_findings": [
    "Rhim (PMID 24856585) versus Ozdemir (PMID 24856586) assignment - checked both ways, correct in prose, inventory, timeline and cards",
    "Aggregation - primary-subclaim on SC2 returns Gamma and SC1's influence scope cannot set the headline under scope-matched; the round-2 aggregation misread is not present",
    "SC1 at Eta - independence basis recorded, names four lines and the distinct error each excludes, counts the two CheckMate 067 reports as one line",
    "Role of mechanism 'reinforcing / stabilizing factor' - step 5 fall-through derived in prose",
    "Stability 'Stable' - no pending result named",
    "v5.claim_form phenomenon warning - rejected-finding convention for this round",
    "v5.lay_summary FAIL under validator 2.4 - v5.4-only requirement, pre-existing on the original, package validates under 2.3",
    "Revision regression check - the revised edition adds only the dated Consensus provenance block relative to the earlier edition and introduces no error",
    "Expression of concern on PMID 26524530 - disclosed, dated and excluded from positive evidence",
    "Confidence band re-tested against the High text after removing access depth: shared CAF lineage and reused expression data, shared MYC/immunoediting platforms and one CheckMate 067 trial line make this the Moderate text; the dominance claim actually graded has no replication at all; band holds",
    "Coordinator-flagged reviewer-notes contradiction: not present; the review carries an affirmative METHODS AND CONSENSUS CONTRIBUTION section that agrees with the spliced block",
    "Best-supported rival renderer defect: models_evaluated[0] here is M4, is_nominal false, rank 1, with the nominal at rank 5; the prose names the rival correctly"
  ],
  "residual_limitations": "Nine partial-body and 55 abstract/status examinations. Body-level figures absent from the abstracts (6.17 to 3.61 months and 15.3 to 43.4 percent in PMID 24856585; approximately 80 percent depletion and 65 versus 47 days in PMID 24856586; 56 percent rebound and 13 to 63 days in PMID 27199435; one of ten donors and 16 of 18 grafts in PMID 15051869) were checked for internal consistency only. Four erratum identifiers remain unsupplied.",
  "files_changed": [
    "tumor-microenvironment-primacy.review.md",
    "tumor-microenvironment-primacy.scorecard.json",
    "validator-adversarial-2026-10-14.txt (new)",
    "ADVERSARIAL_REVIEW.md (new)",
    "adversarial-findings.json (new)"
  ],
  "propagated_to": [],
  "divergent_copies": [
    "hsef_v53_popularity_ranks_31_35_2026-10-08\\tumor-microenvironment-primacy\\tumor-microenvironment-primacy.review.md (earlier edition, left untouched)"
  ],
  "coordinator_round2_artifact_checks": {
    "false_approval_boilerplate": "corrected",
    "confidence_set_from_access_depth": "corrected; band re-tested against the High text and held at Moderate",
    "best_supported_rival_renderer_bug": "checked; models_evaluated[0] is a non-nominal rank-1 model, prose correct",
    "reviewer_notes_contradiction": "not present"
  }
}