{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "A tumor contains cancer cells, immune cells, supporting tissue and blood vessels. This review asks how those surroundings change cancer behavior and whether they generally dominate the genetic programs inside cancer cells.",
  "implications": "Preregistered primary-subclaim SC2 returns Γ. Weakest-link and scope-matched sensitivities also return Γ; SC1 influence reaches Η independently. A narrow macrophage-dependent acquired-resistance state can cross Ε contribution/conditional dominance, but it does not replace the registered broad maintenance/progression claim.",
  "limitations": "64 primary reports with 9 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}