{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Preregistered scope-matched SC3 gives Γ. Vascular cognitive injury reaches Ζ through convergent endogenous perturbations, inherited vasculopathies and randomized human vascular prevention. Those successes do not establish the distinguishing vascular-first AD amyloid/tau sequence. Protein-first injury, rescue without amyloid change, and opposite tau responses remain discriminators.",
  "implications": "Preregistered scope-matched SC3 gives Γ. Vascular cognitive injury reaches Ζ through convergent endogenous perturbations, inherited vasculopathies and randomized human vascular prevention. Those successes do not establish the distinguishing vascular-first AD amyloid/tau sequence. Protein-first injury, rescue without amyloid change, and opposite tau responses remain discriminators.",
  "limitations": "69 primary reports with 7 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}