{
  "score_after": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "Moderate",
    "confidence_rationale": "50 primary reports with 3 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "Overall Γ is a partial-mechanism assessment for the registered broad prevention claim, not a denial of vitamin-D biology or skeletal indications. Robust null trials and attenuated secondary evidence prevent a broad positive causal crossing; genetic and disease-specific findings keep this above a purely associational interpretation."
  },
  "primary_comparisons": [
    {
      "doi": "10.1056/NEJMoa1809944",
      "study_group": "VITAL",
      "access_depth": "Primary RCT report; selected original full-text evidence in frozen ledger source 1",
      "pmid": "30415629",
      "result_comparison": "25,871 adults; no significant total invasive cancer, major CVD, or all-cause mortality reduction. Provider synthesis aligns on null broad prevention; the population is not a direct test of treating frank deficiency."
    },
    {
      "doi": "10.1136/bmj-2023-075230",
      "study_group": "D_HEALTH",
      "access_depth": "Original primary RCT endpoint paper, PubMed abstract; already in frozen selected-records.json/evidence.json source 6, canonical review and appraisals.tsv; D_HEALTH",
      "pmid": "37380191",
      "result_comparison": "21,315 participants, monthly vitamin D; composite MACE HR 0.91 (0.81-1.01), CI includes null; CV-drug subgroup interaction non-significant. Already present in frozen package and shares D_HEALTH cohort; do not count as a new trial."
    },
    {
      "doi": "10.1016/S2213-8587(21)00345-4",
      "study_group": "D_HEALTH",
      "access_depth": "Original primary report abstract; frozen ledger source 12",
      "pmid": "35026158",
      "result_comparison": "Mortality endpoint report from same D-Health RCT; does not establish broad mortality benefit; already present and not an independent cohort."
    },
    {
      "doi": "10.1016/j.jsbmb.2025.106738",
      "study_group": "D_HEALTH",
      "access_depth": "Original primary report abstract; frozen ledger source 10",
      "pmid": "40096917",
      "result_comparison": "Cancer-incidence endpoint report from same randomized cohort; already present; do not treat endpoint publication as an independent trial."
    }
  ],
  "grade_changed": false,
  "raw_paths": [
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    "browser-thread.json",
    "consensus-search-raw.json"
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  "queries": [
    "vitamin D causality chronic diseases (browser request in browser-thread.json)",
    "vitamin D deficiency supplementation randomized trial severe deficiency non skeletal disease incidence D-Health VITAL updated meta-analysis"
  ],
  "cutoff": "2026-10-09",
  "score_before": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "Moderate",
    "confidence_rationale": "50 primary reports with 3 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "Overall Γ is a partial-mechanism assessment for the registered broad prevention claim, not a denial of vitamin-D biology or skeletal indications. Robust null trials and attenuated secondary evidence prevent a broad positive causal crossing; genetic and disease-specific findings keep this above a purely associational interpretation."
  },
  "conclusion": "Consensus citations did not reveal a new independent randomized primary cohort changing the broad registered claim. Supplementation trials and deficiency causality remain distinct.",
  "addendum_path": "deliverables\\consensus_consistency_audit_2026-10-09\\checks\\vitamin-d-deficiency\\addendum.md",
  "original_counts_preserved": {
    "claims_total": 54,
    "sources_total": 50
  },
  "completed": true,
  "independent_blinded_audit": false,
  "provider_mode": "Consensus Pro browser thread plus Consensus keyword search/fetch",
  "source_id_reconciliation": [
    {
      "study_group": "VITAL",
      "status": "present",
      "id": "PMID 30415629 / DOI 10.1056/NEJMoa1809944",
      "location": "selected-records.json/evidence; source 1"
    },
    {
      "study_group": "D_HEALTH",
      "status": "present",
      "id": "PMID 37380191 / DOI 10.1136/bmj-2023-075230",
      "location": "selected-records.json, evidence.json, canonical review, appraisals.tsv; source 6"
    },
    {
      "study_group": "D_HEALTH",
      "status": "present",
      "id": "PMID 35026158 / DOI 10.1016/S2213-8587(21)00345-4",
      "location": "selected-records.json/evidence; source 12"
    },
    {
      "study_group": "D_HEALTH",
      "status": "present",
      "id": "PMID 40096917 / DOI 10.1016/j.jsbmb.2025.106738",
      "location": "selected-records.json/evidence; source 10"
    }
  ],
  "additional_original_source_receipts": [],
  "primary_comparison_count": 4,
  "status": "completed_retrospective_original_source_reconciliation",
  "raw_receipts": [
    {
      "path": "deliverables\\consensus_consistency_audit_2026-10-09\\checks\\vitamin-d-deficiency\\consensus-browser-response.md",
      "sha256": "155e6846b95b4cd9976cdf8c3419ff9ec20350d36a3963f132172bc546e0829c"
    },
    {
      "path": "deliverables\\consensus_consistency_audit_2026-10-09\\checks\\vitamin-d-deficiency\\browser-thread.json",
      "sha256": "99920bc1d0adc01e45fbc34fbbb8a0943ada98633baa9119910bea2a7ff3a29f"
    },
    {
      "path": "deliverables\\consensus_consistency_audit_2026-10-09\\checks\\vitamin-d-deficiency\\consensus-search-raw.json",
      "sha256": "28a6d3df66a8a6e24fd6dac88c4ff34e0105131934e4aaca6901f55c603b95dc"
    }
  ],
  "manifest_source": "deliverables\\consensus_consistency_audit_2026-10-09\\checks\\vitamin-d-deficiency\\final-structured-consensus-validation.json",
  "literature_cutoff_preserved": true
}