{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "The preregistered primary-subclaim rule uses SC2, giving Γ for direct continuous Polycomb scaffolding. SC1 is Η within initiation-competent mammalian contexts, while SC3 is Γ and SC4 Β for their stronger mechanism claims. Weakest-link sensitivity is Β. Evidence for Xist necessity and modular Polycomb causality is retained and cannot replace the nominal structural claim.",
  "implications": "The preregistered primary-subclaim rule uses SC2, giving Γ for direct continuous Polycomb scaffolding. SC1 is Η within initiation-competent mammalian contexts, while SC3 is Γ and SC4 Β for their stronger mechanism claims. Weakest-link sensitivity is Β. Evidence for Xist necessity and modular Polycomb causality is retained and cannot replace the nominal structural claim.",
  "limitations": "65 primary reports with 9 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}