Controlled diets can change intake and weight, while texture and eating rate produce effects within processing categories. Establishing a category-wide effect independent of the properties consumed requires stronger separation of composition, physical structure and proposed mechanisms.
This dated addendum adds selected evidence and tests that could resolve the remaining questions. It does not regrade the archived review.
Each question identifies a limit in the checked evidence. A missing search result alone does not establish a gap in the entire field.
Competing explanation: Eating rate, density or nutrient selection may account for a diet contrast.
Discriminating test: Factorial processing-by-texture designs with measured consumed density/composition, palatability and beverage calories; prespecified category interaction.
Competing explanation: Intake reduction may be compensated later or be too brief to change weight.
Discriminating test: Longer randomized texture interventions within and across processing categories, with total intake, fat mass and compensatory snacking measured.
Competing explanation: Additives may mark other properties; acute satiety may differ from chronic metabolic effects.
Discriminating test: Matched-component/additive and matrix factorial trials with validated exposure, intake and longer outcomes; the current search does not establish absence of all such studies.
Competing explanation: Measured dopamine or insulin may be weak, downstream or unrelated to the observed diet effect.
Discriminating test: Repeated appetite/reward measurements within randomized feeding plus selective model perturbation; separate target engagement, correlation and formal mediation.
Electronic publication dates are used where recorded, with issue years shown separately. This is a selected chronology, not a claim of scientific priority or independent replication for every entry.
The ultra-processed diet increased intake and weight relative to its comparator.
What it cannot establish: Matched offered nutrients do not guarantee matched consumed composition, nonbeverage density or eating rate; corrections retained.
Harder meals slowed intake and reduced energy intake across processing levels.
What it cannot establish: Acute lunch and daily intake measures do not demonstrate long-term adiposity mediation.
Hard texture reduced daily intake; processing-category contrasts were context-dependent.
What it cannot establish: Small preliminary sample and property differences bound an independent category inference.
The tested ultra-processed diet increased intake/weight and reduced chewing per calorie.
What it cannot establish: Short exposure and simultaneous food-property changes do not isolate chewing as mediator.
A milkshake produced no significant average striatal dopamine response by the measured method.
What it cannot establish: A single food and measurement sensitivity do not exclude every reward mechanism.
Both diets reduced weight; the minimally processed diet produced greater loss.
What it cannot establish: This is a relative difference between defined diets, not a claim that all ultra-processed diets cause weight gain.
Slower eating reduced intake within ultra-processed diets; body weight did not differ.
What it cannot establish: No minimally processed comparator; intake effects and weight outcomes must remain distinct.
Acute insulin differences were reported without a density interaction.
What it cannot establish: Secondary exploratory hormonal findings do not establish the appetite/weight mediator.
Processing did not affect subsequent intake or short-term satiety in the tested design.
What it cannot establish: Acute preload results do not refute every longer whole-diet effect; shares a registry with source 10.
Case-specific Consensus records assisted gap discovery, chronology and targeted paper questions. Shared template wording about an amyloid-specific Deep follow-up is not evidence of a Deep run for this topic; the dated source records establish the actual use and access limits. Primary identifiers, selected abstract passages, correction notices and available primary-body passages were cross-checked. Generated absence cells, duplicate milestones and unsupported access claims were rejected.
Results Par35/38: a daily texture-associated intake effect and meal-specific palatability differences. No consumed-density matching was assumed from as-served menus.
This focused addendum does not establish 50–70 complete primary Methods/Results examinations per review. Baseline reading receipts and scores retain their original scope.
Selected full-text checks: 1; abstract checks: 8; metadata-only anchors: 0. Complete-paper examinations credited in this update: 0.
New enrichment: HSEF v5.3 causal distinctions. Archived scorecard schema: 5.4; retained as recorded.
A generated Consensus timeline caption incorrectly referred to CRISPR. It was discarded. Forde has a 2026 issue date and 2025 electronic date; hormonal and preload reports sharing a registry are not independent cohorts.
PMID 31105044 · DOI 10.1016/j.cmet.2019.05.008
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
Linked notices: Correction 31269427 · Correction 33027677
Linked notice presence was checked in the primary record; its scientific impact was not verified in this update.
PMID 35285882 · DOI 10.1093/ajcn/nqac068
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 37452167 · DOI 10.1007/s00394-023-03202-z
Selected full-text passages checked. Results Par35/38: a daily texture-associated intake effect and meal-specific palatability differences. No consumed-density matching was assumed from as-served menus.
PMID 39267249 · DOI 10.1111/dom.15922
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 40760353 · DOI 10.1038/s41591-025-03842-0
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 40043691 · DOI 10.1016/j.cmet.2025.02.002
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 41314613 · DOI 10.1016/j.ajcnut.2025.11.012
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 42588167 · DOI 10.3390/nu18152534
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 42633852 · DOI 10.1016/j.appet.2026.108761
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
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